Drug Combination Details

General Information of the Combination (ID: C60150)
Name Misoprostol   NP Info  + Mifepristone   Drug Info 
Structure +
Disease
Abortion [ICD-11: JA00]
Phase 4 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vivo Model Retrospective clinical study
                    Experimental
                    Result(s)		 The addition of mifepristone to medical treatment regimens for first trimester miscarriage significantly decreased the need for repeat medical dosing and surgical curettage.
References
Reference 1 ClinicalTrials.gov (NCT01768299) Medical Abortion With Mifepristone + Misoprostol (13 - 22 Weeks).
Reference 2 Combination therapy with mifepristone and misoprostol for the management of first trimester miscarriage: Improved success. Aust N Z J Obstet Gynaecol. 2018 Aug;58(4):438-442.
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