| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Enhancing Drug Efficacy by This Combination |
| Achieving Therapeutic Synergy |
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| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vivo Model |
At the age of 10 weeks, DBA/1 mice were immunized intradermally at the base of the tail with 0.1 ml of emulsion containing 100 ug of type II collagen. |
Experimental
Result(s) |
Doxycycline and hAAT in combination also inhibited IL-6 expression from LPS-stimulated NIH/3T3 mouse fibroblast cells, indicating a contributing mechanism of arthritis inhibition. |
