| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally |
| α. Enhancing Drug Efficacy by This Combination |
| Achieving Therapeutic Synergy |
Click to Show/Hide |
| Experiment 1 Reporting the Effect of This Combination |
[1] |
| In-vivo Model |
The left kidney of the donor rat (Fisher F344) was perfused through the aorta with 4 degree centigrade heparinized Ringer's lactate solution and harvested, after transecting the ureter, the renal artery close to the aorta, and the renal vein near the vena cava. The recipient rat was anesthetized and a left nephrectomy was performed after transecting the renal artery, the renal vein, and the ureter. |
Experimental
Result(s) |
Over a 50-week study, concomitant therapy of MMF and RAPA prevents chronic renal allograft rejection, probably through reduction of ischemic and cytotoxic degenerative changes. |
