Drug Combination Details

General Information of the Combination (ID: C62408)
Name Xanthotoxin + Ketoconazole + Amphotericin B
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Name Xanthotoxin   NP Info     Drug Info 
Structure
Name    Drug Info 
Structure
Disease
Candidosis [ICD-11: 1F23]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Candida albicans ATCC 22972 Microorganism model Candida albicans
Candida glabrata ATCC 90525 Microorganism model Candida glabrata
Candida guilliermondii ATCC 20216 Microorganism model Candida guilliermondii
Candida krusei ATCC 6258 Microorganism model Candida krusei
Candida parapsilosis ATCC 7330 Microorganism model Candida parapsilosis
Candida tropicalis ATCC 42678 Microorganism model Candida tropicalis
                    Experimental
                    Result(s)		 1/2 MIC dose of xanthorrhizol in combination with 1/2 MIC dose of ketoconazole or 1/2 MIC dose of amphotericin B exhibited growth inhibition of all Candida species tested and reduced viable cells by several logs within 4 h.
References
Reference 1 Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B. FEMS Yeast Res. 2009 Dec;9(8):1302-11.
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