Drug Combination Details
| General Information of the Combination (ID: C62728) | |||||
|---|---|---|---|---|---|
| Name | Vitamin E NP Info | + | Aspirin Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Rheumatoid arthritis
[ICD-11: FA20]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
|
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| In-vitro Model | J774.1A | Mouse reticulum cell sarcoma | Mus musculus | |||
| Experimental
Result(s) |
Anti-inflammatory therapy might be successful with lower aspirin doses when combined with vitamin E, thereby possibly avoiding the side effects of the usually required high dose aspirin treatment. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. Free Radic Biol Med. 2000 Dec;29(11):1135-42. | |||
