Drug Combination Details
| General Information of the Combination (ID: C63930) | |||||
|---|---|---|---|---|---|
| Name | Metformin NP Info | + | Rapamycin Drug Info | ||
| Structure |
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+ |
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| Disease |
Pancreatic cancer
[ICD-11: 2C10]
|
Phase 1 | [1] | ||
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Aging
[ICD-11: MG2A]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vivo Model | The in vovo experiment was carried out with male Wistar rats. | |||||
| Experimental
Result(s) |
Cotreatment with rapamycin and metformin showed a significant augmented effect compared with individual drug interventions on reversal of these age-dependent biomarkers of oxidative stress, suggesting a synergistic response. | |||||
