Drug Combination Details

General Information of the Combination (ID: C64666)
Name 1,8-cineole + Clavulanate + Amoxicillin
    Click to Show/Hide the Each NP or Drug Information of This Combination
Name 1,8-cineole   NP Info     Drug Info 
Structure
Name Clavulanate   NP Info 
Structure
Disease
Osteomyelitis [ICD-11: FB84]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vivo Model Forty-two female New Zealand white rabbits (5-6 weeks old), weighing between 1.2 and 1.8 kg were used in this study.
                    Experimental
                    Result(s)		 The combination of the AMC with gentamicin did not induce a synergistic effect, whereas the combination of the two antibiotics with 1,8-cineole did.
References
Reference 1 The Antistaphylococcal Activity of Amoxicillin/Clavulanic Acid, Gentamicin, and 1,8-Cineole Alone or in Combination and Their Efficacy through a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Osteomyelitis. Evid Based Complement Alternat Med. 2020 Apr 28;2020:4271017.
 Download Picture         KEGG Link