Drug Combination Details
| General Information of the Combination (ID: C65878) | |||||
|---|---|---|---|---|---|
| Name | Vincristine NP Info | + | Volasertib Drug Info | ||
| Structure |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Phase 1 | [1] | ||
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Rhabdomyosarcoma
[ICD-11: 2B55]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | A-204 | CVCL_1058 | Embryonal rhabdomyosarcoma | Homo sapiens | ||
| RD | CVCL_1649 | Embryonal rhabdomyosarcoma | Homo sapiens | |||
| Rh18 | CVCL_1659 | Alveolar rhabdomyosarcoma | Homo sapiens | |||
| Rh30 | CVCL_0041 | Alveolar rhabdomyosarcoma | Homo sapiens | |||
| Rh41 | CVCL_2176 | Alveolar rhabdomyosarcoma | Homo sapiens | |||
| RMS-1 | CVCL_UF94 | Embryonal rhabdomyosarcoma | Homo sapiens | |||
| RMS-YM | CVCL_A792 | Embryonal rhabdomyosarcoma | Homo sapiens | |||
| Experimental
Result(s) |
Volasertib exhibits antitumor activity and synergy with vincristine in alveolar rhabdomyosarcoma. | |||||
