Drug Combination Details

General Information of the Combination (ID: C67017)
Name Resveratrol   NP Info  + Ivacaftor   Drug Info 
Structure +
Disease
Cystic fibrosis [ICD-11: CA25]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model Cells derived from cystic fibrosis patients Cystic fibrosis Homo sapiens
Fisher rat thyroid cells Healthy Rattus norvegicus
                    Experimental
                    Result(s)		 Additive improvement in G551D CFTR-mediated Cl-secretion suggests that resveratrol could enhance ivacaftor therapy in these patients and improve CF-related rhinosinusitis.
References
Reference 1 Resveratrol and ivacaftor are additive G551D CFTR-channel potentiators: therapeutic implications for cystic fibrosis sinus disease. Int Forum Allergy Rhinol. 2019 Jan;9(1):100-105.
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