Drug Combination Details
| General Information of the Combination (ID: C67961) | |||||
|---|---|---|---|---|---|
| Name | Hypericin NP Info | + | N-acetylcysteine Drug Info | ||
| Structure |
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+ |
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| Disease |
Staphylococcus infection
[ICD-11: 1C41]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Increase | Mature biofilm disruption | ||||
| In-vitro Model | Staphylococcus aureus | Microorganism model | Staphylococcus aureus | |||
| Experimental
Result(s) |
HYP-PDI in combination with AC had significant ability to eradicate the pre-formed mature biofilms of S. aureus strains. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Phototoxic effect of hypericin alone and in combination with acetylcysteine on Staphylococcus aureus biofilms. Photodiagnosis Photodyn Ther. 2015 Jun;12(2):186-92. | |||
