Drug Combination Details

General Information of the Combination (ID: C68176)
Name Pitavastatin   NP Info  + Pemafibrate   Drug Info 
Structure +
Disease
Atherosclerosis [ICD-11: BD40]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Up-regulation Expression NOS3  Molecule Info 
Pathway MAP
                    In-vivo Model For a xenograft model, seven-week-old male Dahl salt-sensitive (DS) rats were fed a normal diet (ND; 0.3% NaCl and 4.5% fat) or a high-salt and high-fat diet (HD; 8% NaCl and 29.4% fat).
                    Experimental
                    Result(s)		 Combination therapy with pitavastatin and pemafibrate improved lipid profiles including TG and cholesterol levels and ameliorated endothelial dysfunction.
References
Reference 1 Combination therapy with pemafibrate (K-877) and pitavastatin improves vascular endothelial dysfunction in dahl/salt-sensitive rats fed a high-salt and high-fat diet. Cardiovasc Diabetol. 2020 Sep 26;19(1):149.
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