Drug Combination Details
| General Information of the Combination (ID: C69596) | |||||
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| Name | 1,8-cineole + Clavulanate | + | Amoxicillin + Gentamicin | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | 1,8-cineole NP Info | Drug Info | |||
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| Name | Clavulanate NP Info | Drug Info | |||
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| Disease |
Osteomyelitis
[ICD-11: FB84]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Staphylococcus aureus | Microorganism model | Staphylococcus aureus | |||
| Susceptible Saureus | Microorganism model | Susceptible Saureus | ||||
| In-vivo Model | Forty-two female New Zealand white rabbits were used as animal model in this study. | |||||
| Experimental
Result(s) |
1,8-cineole showed a synergistic effect in combination with both AMC and gentamicin, which offer possibilities for reducing antibiotic usage. | |||||
