Drug Combination Details
| General Information of the Combination (ID: C69618) | |||||
|---|---|---|---|---|---|
| Name | Silibinin NP Info | + | Dicyclohexylcarbodiimide Drug Info | ||
| Structure |
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| Disease |
Pneumonia
[ICD-11: CA40]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Enterococcus faecium | Microorganism model | Enterococcus faecium | |||
| Escherichia coli | Microorganism model | Escherichia coli | ||||
| Pseudomonas aeruginosa | Microorganism model | Pseudomonas aeruginosa | ||||
| Experimental
Result(s) |
Silybin showed a remarkable synergistic activity in combination with some antibiotic agents against drug-resistant bacteria. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic antibacterial effect between silybin and N,N'-dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates. J Microbiol. 2008 Aug;46(4):462-7. | |||
