Drug Combination Details
| General Information of the Combination (ID: C70559) | |||||
|---|---|---|---|---|---|
| Name | Moxonidine NP Info | + | Hydrochlorothiazide Drug Info | ||
| Structure |
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+ |
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| Disease |
Hypertension
[ICD-11: BA00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Clinical trial | |||||
| Experimental
Result(s) |
This profile of moxonidine is highly comparable to a standard first-line antihypertensive drug such as hydrochlorothiazide, without sacrificing tolerance and safety for increased efficacy, in combination with hydrochlorothiazide. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Moxonidine and hydrochlorothiazide in combination: a synergistic antihypertensive effect. J Cardiovasc Pharmacol. 1994;24 Suppl 1:S25-8. | |||
