Drug Combination Details
| General Information of the Combination (ID: C71898) | |||||
|---|---|---|---|---|---|
| Name | Plumbagin NP Info | + | Gentamicin Drug Info | ||
| Structure |
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| Disease |
Chronic obstructive pulmonary disease
[ICD-11: CA22]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Klebsiella pneumoniae | Microorganism model | Klebsiella pneumoniae | |||
| Experimental
Result(s) |
Herbal compound plumbagin was identified to stimulate gentamicin uptake by CRKp via enhancing TCA efflux and PMF to achieve a synergistic antibacterial effect. Plumbagin may be used in combination with aminoglycosides for severe CRKp infection by potentiating their therapeutic efficacy and lowering dosage. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic Effect and Mechanism of Plumbagin with Gentamicin Against Carbapenem-Resistant Klebsiella pneumoniae. Infect Drug Resist. 2020 Aug 7;13:2751-2759. | |||
