Drug Combination Details

General Information of the Combination (ID: C72890)
Name Fucoxanthin   NP Info  + 5-fluorouracil   Drug Info 
Structure +
Disease
Colorectal cancer [ICD-11: 2B91]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Induction DNA damage
                    In-vitro Model HCT 116 CVCL_0291 Colon carcinoma Homo sapiens
HT29 CVCL_A8EZ Colorectal adenocarcinoma Mus musculus
                    Experimental
                    Result(s)		 Since Phloroglucinol and Fucoxanthin alone reduced cancer cell line viability without an effect on normal cells and when in combination enhanced the cytotoxic effect of 5-Fu only in colon cancer cells.
References
Reference 1 Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells. J Toxicol Environ Health A. 2017;80(13-15):776-787.
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