Drug Combination Details
| General Information of the Combination (ID: C73865) | |||||
|---|---|---|---|---|---|
| Name | Thymoquinone NP Info | + | Cyclophosphamide Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | FASN | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | HER2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PTEN | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-BR-3 | CVCL_0033 | Breast adenocarcinoma | Homo sapiens | ||
| MDA-231 | Breast cancer | Homo sapiens | ||||
| Experimental
Result(s) |
TQ can broadly augment the effect of cyclo in breast cancer cases irrespective of Her-2+ or Her-. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells. Asian Pac J Cancer Prev. 2019 Apr 29;20(4):1153-1160. | |||
