Drug Combination Details

General Information of the Combination (ID: C74864)
Name Piperine   NP Info  + TNF-related apoptosis inducing ligand    Drug Info 
Structure +
Disease
Breast cancer [ICD-11: 2C60]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Phosphorylation RELA  Molecule Info 
Pathway MAP
                    In-vitro Model MDA-MB-468 CVCL_0419 Breast adenocarcinoma Homo sapiens
MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
4T1 CVCL_0125 Malignant neoplasms Mus musculus
                    In-vivo Model 1*105 4T1-luc murine cells were inoculated directly into the mouse mammary fat pad.
                    Experimental
                    Result(s)		 Piperine enhances TRAIL-based therapeutics for TNBC.
References
Reference 1 Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells. Anticancer Res. 2014 Apr;34(4):1893-9.
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