Drug Combination Details

General Information of the Combination (ID: C75715)
Name Shikonin   NP Info  + Dimethylaminoparthenolide   Drug Info 
Structure +
Disease
Acute lymphoblastic leukemia [ICD-11: 2B33]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Alteration Cellular metabolism
                    In-vitro Model Kasumi-2 CVCL_0590 B acute lymphoblastic leukemia Homo sapiens
KOPN-8 CVCL_1866 B acute lymphoblastic leukemia Homo sapiens
NALM-6 CVCL_0092 Adult B acute lymphoblastic leukemia Homo sapiens
RCH-ACV CVCL_1851 B acute lymphoblastic leukemia Homo sapiens
Reh CVCL_1650 B acute lymphoblastic leukemia Homo sapiens
                    Experimental
                    Result(s)		 Combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor-B cell acute lymphoblastic leukemia.
References
Reference 1 Identification of a synergistic combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor-B cell acute lymphoblastic leukemia. Mol Carcinog. 2020 Apr;59(4):399-411.
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