Drug Combination Details
| General Information of the Combination (ID: C76194) | |||||
|---|---|---|---|---|---|
| Name | Levodopa NP Info | + | Celecoxib Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Parkinson's disease
[ICD-11: 8A00]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Parkinsonian rats were used as animal model in this study. | |||||
| Experimental
Result(s) |
L-DOPA + celecoxib combination produces an antiallodynic and antihyperalgesic synergistic interaction at the systemic level, and these effects are mediated, at the central level, through activation of the NO-cGMP-ATP-sensitive K+ channel pathway. | |||||
