Drug Combination Details

General Information of the Combination (ID: C77710)
Name Salinomycin   NP Info  + Gemcitabine   Drug Info 
Structure +
Disease
Pancreatic cancer [ICD-11: 2C10]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Augmenting Drug Sensitivity     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model SW1990 CVCL_1723 Pancreatic adenocarcinoma Homo sapiens
AsPC-1 CVCL_0152 Pancreatic ductal adenocarcinoma Homo sapiens
                    In-vivo Model SW1990 cells were injected subcutaneously into the right flank of nude mice using a 23-gauge needle at a 2*106 cells per mouse.
                    Experimental
                    Result(s)		 Salinomycin combined with gemcitabine could eliminate the engraftment of human pancreatic cancer more effectively than the individual agents.
References
Reference 1 Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells. Cancer Lett. 2011 Dec 27;313(2):137-44.
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