Drug Combination Details

General Information of the Combination (ID: C79794)
Name Delta-9-tetrahydrocannabinol   NP Info  + Temozolomide   Drug Info 
Structure +
Disease
Brain cancer [ICD-11: 2A00]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model U-87MG ATCC CVCL_0022 Glioblastoma Homo sapiens
T98G CVCL_0556 Glioblastoma Homo sapiens
HG19 cells isolated from brain tumor biopsies Brain tumor Homo sapiens
                    In-vivo Model Tumors were induced in nude mice by subcutaneous injection of 5 * 106 U87 cells or 10 *106 T98 cells in PBS supplemented with 0.1% glucose.
                    Experimental
                    Result(s)		 The combined administration of Delta(9)-Tetrahydrocannabinol and temozolomide exerts a strong antitumoral action in glioma xenografts, an effect that is also observed in tumors that are resistant to TMZ treatment.
References
Reference 1 A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther. 2011 Jan;10(1):90-103.
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