Drug Combination Details
| General Information of the Combination (ID: C80324) | |||||
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| Name | Fluoroorotic acid | + | Raltitrexed + 5-fluorouracil | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Fluoroorotic acid NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
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| Disease |
Metastatic lymph node neoplasm
[ICD-11: 2D60]
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Investigative | [1] | ||
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Colon cancer
[ICD-11: 2B90]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | LoVo | CVCL_0399 | Colon adenocarcinoma | Homo sapiens | ||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation. | |||||
