Drug Combination Details

General Information of the Combination (ID: C80401)
Name Metformin   NP Info  + Valproic acid   Drug Info 
Structure +
Disease
Prostate cancer [ICD-11: 2C82]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression TP53  Molecule Info 
Pathway MAP
                    In-vitro Model LNCaP CVCL_0395 Prostate carcinoma Homo sapiens
PC-3 CVCL_0035 Prostate carcinoma Homo sapiens
                    Experimental
                    Result(s)		 MET + VPA induced a significant decrease in proliferation and an increase in apoptosis in tumor cells.
References
Reference 1 The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. Mol Cancer Ther. 2017 Dec;16(12):2689-2700.
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