Drug Combination Details
| General Information of the Combination (ID: C80620) | |||||
|---|---|---|---|---|---|
| Name | Coumarins NP Info | + | Cisplatin Drug Info | ||
| Structure |
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| Disease |
Melanoma
[ICD-11: 2C30]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | FM55p | CVCL_C591 | Cutaneous melanoma | Homo sapiens | ||
| FM55M2 | CVCL_C590 | Cutaneous melanoma | Homo sapiens | |||
| Experimental
Result(s) |
The combination of CDDP and osthole was characterized by the most desirable synergistic interaction. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergy, Additivity, and Antagonism between Cisplatin and Selected Coumarins in Human Melanoma Cells. Int J Mol Sci. 2021 Jan 7;22(2):537. | |||
