Drug Combination Details
| General Information of the Combination (ID: C81199) | |||||
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| Name | Fosfomycin | + | Ceftazidime + Avibactam | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Fosfomycin NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
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| Disease |
Pneumonia
[ICD-11: CA40]
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Investigative | [1] | ||
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Chronic obstructive pulmonary disease
[ICD-11: CA22]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | Klebsiella pneumoniae clinical strains | Microorganism model | Klebseilla pneumoniae | |||
| Experimental
Result(s) |
The combinations of ceftazidime-avibactam with ertapenem, and ceftazidime-avibactam with tigecycline were able to reduce the MIC to less than the susceptibility breakpoint in all KPC- and OXA-48-producing K. pneumoniae. | |||||
