Drug Combination Details
| General Information of the Combination (ID: C81544) | |||||
|---|---|---|---|---|---|
| Name | Penciclovir NP Info | + | lamivudine Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatitis C virus infection
[ICD-11: 1E51]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Huh-7 | CVCL_0336 | Adult hepatocellular carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
These results suggest that combinations of 3TC and PCV may act synergistically against HBV in vivo. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro. Hepatology. 1997 Jul;26(1):216-25. | |||
