Drug Combination Details
| General Information of the Combination (ID: C82649) | |||||
|---|---|---|---|---|---|
| Name | Caffeine citrate NP Info | + | Cisplatin Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Osteosarcoma
[ICD-11: 2B51]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Up-regulation | Cell cycle arrest in G0/G1 phase | ||||
| In-vitro Model | HOS | CVCL_0312 | Osteosarcoma | Homo sapiens | ||
| HT-1080 | CVCL_0317 | Fibrosarcoma | Homo sapiens | |||
| DLM8 | CVCL_6669 | Mouse osteosarcoma | Mus musculus | |||
| In-vivo Model | LM8 and HT1080 cells were suspended (5 * 105 cells/100 ul) in Matrigel and injected subcutaneously into female athymic nude mice. | |||||
| Experimental
Result(s) |
Cisplatin combined with caffeine citrate significantly reinforced the anticancer effect compared with cisplatin alone, combination of cisplatin and anhydrous caffeine, and combination of cisplatin and citric acid. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo. BMC Cancer. 2019 Jul 15;19(1):689. | |||
