Drug Combination Details
| General Information of the Combination (ID: C84557) | |||||
|---|---|---|---|---|---|
| Name | Testosterone NP Info | + | Letrozole Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Constitutional delay of growth and puberty
[ICD-11: MG44]
|
Phase 3 | [1] | ||
|
Osteoporosis
[ICD-11: FB83]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vivo Model | A total of 48 adult (8 weeks old) male Sprague-Dawley rats with mean weight of 250-300 gr were enrolled in this study. | |||||
| Experimental
Result(s) |
Both testosterone and its combination with letrozole increased lumbar and femoral BMD of orchiectomized rats, with a higher increase in lumbar BMD in O + T group. | |||||
