Drug Combination Details

General Information of the Combination (ID: C85964)
Name Toremifene   NP Info  + Atamestane   Drug Info 
Structure +
Disease
Breast cancer [ICD-11: 2C60]
Phase 3 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    In-vitro Model MCF-7 CVCL_0031 Invasive breast carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone.
References
Reference 1 ClinicalTrials.gov (NCT00010322) Toremifene With or Without Atamestane in Treating Postmenopausal Women With Metastatic Breast Cancer.
Reference 2 Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):1-7.
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