Drug Combination Details
| General Information of the Combination (ID: C86349) | |||||
|---|---|---|---|---|---|
| Name | Zerumbone NP Info | + | Nimesulide Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Colitis
[ICD-11: 1A40]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
|
|
| In-vivo Model | Colitis was induced in female ICR mice at 7 weeks of age. | |||||
| Experimental
Result(s) |
ZER is a novel food factor for mitigating experimental UC and that use of a combination of agents, with different modes of actions, may be an effective anti-inflammatory strategy. | |||||
