Drug Combination Details

General Information of the Combination (ID: C86482)
Name Colistin   NP Info  + N-acetylcysteine   Drug Info 
Structure +
Disease
Pneumonia [ICD-11: CA40]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Reversing Drug Resistance by This Combination
                 Reversing Drug Resistance     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Biological
                    Regulation		 Increase Biofilm susceptibility
                    In-vitro Model Acinetobacter baumannii Microorganism model Acinetobacter baumannii
                    Experimental
                    Result(s)		 N-acetylcysteine, at concentrations achievable by topical administration, was shown to revert the colistin-resistant phenotype in A. baumannii, and to exert a relevant activity against biofilms of colistin-susceptible and colistin-resistant A. baumannii strains.
References
Reference 1 In vitro synergism of colistin in combination with N-acetylcysteine against Acinetobacter baumannii grown in planktonic phase and in biofilms. J Antimicrob Chemother. 2018 Sep 1;73(9):2388-2395.
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