Drug Combination Details

General Information of the Combination (ID: C90820)
Name Genistein   NP Info  + Decitabine   Drug Info 
Structure +
Disease
Acute lymphoblastic leukemia [ICD-11: 2B33]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model HL-60 CVCL_0002 Adult acute myeloid leukemia Homo sapiens
MOLT-3 CVCL_0624 Adult T acute lymphoblastic leukemia Homo sapiens
L1210 CVCL_0382 Mouse leukemia Mus musculus
                    In-vivo Model Male CD2F1 mice (24-28 g) were injested with L1210 leukemic cells intravenously into the lateral tail vein.
                    Experimental
                    Result(s)		 The combined treatment produced a synergistic loss of clonogenicity in human myeloid (HL-60) and lymphoid (MOLT-3) leukemic cell lines.
References
Reference 1 Synergistic effect of 5-Aza-2'-deoxycytidine and genistein in combination against leukemia. Oncol Res. 2008;17(5):223-30.
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