Drug Combination Details
| General Information of the Combination (ID: C91732) | |||||
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| Name | Xanthotoxin | + | Levetiracetam + Valproic acid | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Xanthotoxin NP Info | Drug Info | |||
| Structure |
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| Name | Drug Info | ||||
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| Disease |
Epilepsy/seizure
[ICD-11: 8A60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Adult male Albino Swiss mice weighing 22-26 g were used in this study. | |||||
| Experimental
Result(s) |
XANT in combination with levetiracetam exerts beneficial anticonvulsant pharmacodynamic interactions in the 6 Hz mouse psychomotor seizure model. | |||||
| References | ||||
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| Reference 1 | Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6-Hz corneal stimulation model in mice. Fundam Clin Pharmacol. 2021 Jul 2. | |||
