Drug Combination Details
| General Information of the Combination (ID: C95441) | |||||
|---|---|---|---|---|---|
| Name | Vincristine NP Info | + | Methotrexate Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | MOLT-3 | CVCL_0624 | Adult T acute lymphoblastic leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Simultaneous exposure of VCR and MTX produced subadditive or mutually protective interactions. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture. Cancer Res. 1988 Jan 15;48(2):351-6. | |||
