Drug Combination Details

General Information of the Combination (ID: C96350)
Name Tazarotene   NP Info  + Imiquimod   Drug Info 
Structure +
Disease
Lentigo maligna [ICD-11: 2E63]
Clinical trial [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [2]
                    Experimental
                    Result(s)		 Tazarotene enhanced the penetration of imiquimod, and could be a therapeutic option in cases where surgical intervention is not possible.
References
Reference 1 ClinicalTrials.gov (NCT00707174) Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna.
Reference 2 Lentigo maligna successfully treated with combination therapy of topical tazarotene and imiquimod. Clin Exp Dermatol. 2017 Jun;42(4):468-470.
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