Drug Combination Details
| General Information of the Combination (ID: C97927) | |||||
|---|---|---|---|---|---|
| Name | Polymyxin B NP Info | + | Mitotane Drug Info | ||
| Structure |
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| Disease |
Pneumonia
[ICD-11: CA40]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vitro Model | Acinetobacter baumannii ATCC 17978 | Microorganism model | Acinetobacter baumannii | |||
| Acinetobacter baumannii ATCC 19606 | Microorganism model | Acinetobacter baumannii | ||||
| Acinetobacter baumannii FADDI-AB225 | Microorganism model | Acinetobacter baumannii | ||||
| Acinetobacter baumannii FADDI-AB065 | Microorganism model | Acinetobacter baumannii | ||||
| Experimental
Result(s) |
The disruption of the citric acid cycle and inhibition of nucleotide biogenesis are the key metabolic features associated with synergistic bacterial killing by the combination against polymyxin-susceptible and -resistant A. baumannii. | |||||
