Drug Combination Details

General Information of the Combination (ID: C98009)
Name Beta asarone   NP Info  + Temozolomide   Drug Info 
Structure +
Disease
Brain cancer [ICD-11: 2A00]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    Molecule(s)
                    Regulation		 Down-regulation Expression ABCB1  Molecule Info 
Pathway MAP
                    In-vitro Model U-251MG CVCL_0021 Astrocytoma Homo sapiens
                    Experimental
                    Result(s)		 Beta-asarone could promote the entry of TMZ into U252 cells through the membrane.
                    Experiment 2 Reporting the Effect of This Combination [2]
                    Molecule(s)
                    Regulation		 Down-regulation Expression ABCB1  Molecule Info 
Pathway MAP
                    In-vitro Model U-251MG CVCL_0021 Astrocytoma Homo sapiens
                    Experimental
                    Result(s)		 Beta-asarone could promote the entry of TMZ into U251 cells through the membrane.
References
Reference 1 Antioxidant and selective anticancer activities of two Euphorbia species in human acute myeloid leukemia. Biomed Pharmacother. 2017 Jun;90:375-385.
Reference 2 Beta-Asarone promotes Temozolomide's entry into glioma cells and decreases the expression of P-glycoprotein and MDR1. Biomed Pharmacother. 2017 Jun;90:368-374.
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