Drug Details

General Information of the Drug (ID: DR0409)
Name
DNMT Inhibitor
Synonyms
Guadecitabine 929901-49-5 SGI-110 SGI-110 free acid 2KT4YN1DP7
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Molecular Type
Small molecule
Disease Bladder cancer [ICD-11: 2C94] Investigative
Structure
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2D MOL

3D MOL

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Formula
C18H24N9O10P
PubChem CID
135564655
Canonical SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)O[C@H]4C[C@@H](O[C@@H]4CO)N5C=NC(=NC5=O)N)O
InChI
InChI=1S/C18H24N9O10P/c19-16-22-6-27(18(31)25-16)12-2-8(9(3-28)35-12)37-38(32,33)34-4-10-7(29)1-11(36-10)26-5-21-13-14(26)23-17(20)24-15(13)30/h5-12,28-29H,1-4H2,(H,32,33)(H2,19,25,31)(H3,20,23,24,30)/t7-,8-,9+,10+,11+,12+/m0/s1
InChIKey
GUWXKKAWLCENJA-WGWHJZDNSA-N
CAS Number
929901-49-5
ChEBI ID
CHEBI:231603
DrugBank ID
DB11918
Target and Pathway
Target(s) Forkhead box protein O1A (FOXO1)  Molecule Info