Drug Details

General Information of the Drug (ID: DR1642)
Name
Pinostrobin
Synonyms
Pinostrobin; 480-37-5; Pinostrombin; Pinocembrin-7-methylether; UNII-SZD9LZS694; SZD9LZS694; CHEMBL254613; (S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4-benzopyrone; CHEBI:80491; (2s)-5-hydroxy-7-methoxyflavanone; 5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one; (2S)-5-hydroxy-7-methoxy-2-phenyl-2,3-dihydrochromen-4-one; pinocembrin-7-methyl ether; dihydrotectochrysin; (-)-pinostrobin; (2S)-pinostrobin; (2S)-5-hydroxy-7-methoxy-2-phenyl-chroman-4-one; SCHEMBL7648566; DTXSID50963979; ZINC391894; Pinostrobin, >=99.0% (TLC); HY-N2127; EINECS 207-548-1; BDBM50338968; (+/-)-5-hydroxy-7-methoxyflavanone; AKOS037515398; CCG-262304; NCGC00163610-01; 5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one; CS-0018678; C16419; 480P375; SR-05000013704; SR-05000013704-1; Q27149542; 5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one; (2S)-5-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (S)-
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Molecular Type
Small molecule
Disease Parkinson's disease [ICD-11: 8A00] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C16H14O4
PubChem CID
73201
Canonical SMILES
COC1=CC(=C2C(=O)CC(OC2=C1)C3=CC=CC=C3)O
InChI
1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1
InChIKey
ORJDDOBAOGKRJV-AWEZNQCLSA-N
CAS Number
CAS 480-37-5
ChEBI ID
CHEBI:80491
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Acacetin      Acacia farnesiana     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
T-47D CVCL_0553 Invasive breast carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Acacetin and Pinostrobin inhibit malignant breast epithelial cell adhesion and focal adhesion formation to attenuate cell migration.
Target and Pathway
Target(s) Hexokinase-2 (HK2)  Molecule Info  [3]
KEGG Pathway Glycolysis/Gluconeogenesis Click to Show/Hide
2 Fructose and mannose metabolism
3 Galactose metabolism
4 Starch and sucrose metabolism
5 Amino sugar and nucleotide sugar metabolism
6 Neomycin, kanamycin and gentamicin biosynthesis
7 Metabolic pathways
8 Carbon metabolism
9 HIF-1 signaling pathway
10 Insulin signaling pathway
11 Type II diabetes mellitus
12 Carbohydrate digestion and absorption
13 Central carbon metabolism in cancer
References
Reference 1 Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction. J Agric Food Chem. 2018 Aug 8;66(31):8307-8318.
Reference 2 Acacetin and Pinostrobin Inhibit Malignant Breast Epithelial Cell Adhesion and Focal Adhesion Formation to Attenuate Cell Migration. Integr Cancer Ther. Jan-Dec 2020;19:1534735420918945.
Reference 3 3-Bromopyruvate: targets and outcomes. J Bioenerg Biomembr. 2012 Feb;44(1):7-15.
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