Drug Details

General Information of the Drug (ID: DR2147)
Name
Recombinant tissue plasminogen activator
Disease Pulmonary thromboembolism [ICD-11: BB00] Phase 4 [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug
          Anisodine      Hyoscyamus niger     Click to Show/Hide the Molecular Data of This NP
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Clinical trial
                    Experimental
                    Result(s)		 Intravenous thrombolysis with rt-PA combined with compound anisodine is safe and effective in treating CRAO, which can significantly improve the prognosis of patients.
Target and Pathway
Target(s) Sphingosine kinase 1 (SPHK1)  Molecule Info  [3]
Sphingosine kinase 2 (SPHK2)  Molecule Info  [3]
BioCyc Sphingosine and sphingosine-1-phosphate metabolism Click to Show/Hide
KEGG Pathway Sphingolipid metabolism Click to Show/Hide
2 Metabolic pathways
3 Calcium signaling pathway
4 Sphingolipid signaling pathway
5 VEGF signaling pathway
6 Fc gamma R-mediated phagocytosis
7 Tuberculosis
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
2 TNFalpha Signaling Pathway
Panther Pathway Angiogenesis Click to Show/Hide
2 VEGF signaling pathway
Pathwhiz Pathway Sphingolipid Metabolism Click to Show/Hide
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells Click to Show/Hide
2 Beta3 integrin cell surface interactions
3 S1P1 pathway
4 Sphingosine 1-phosphate (S1P) pathway
5 PDGFR-beta signaling pathway
6 IL12-mediated signaling events
7 Ceramide signaling pathway
Reactome Sphingolipid de novo biosynthesis Click to Show/Hide
2 VEGFR2 mediated cell proliferation
WikiPathways Signal Transduction of S1P Receptor Click to Show/Hide
2 Protein folding
3 Sphingolipid Metabolism
References
Reference 1 ClinicalTrials.gov (NCT00781378) Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in China
Reference 2 Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. Exp Ther Med. 2016 Oct;12(4):2617-2621.
Reference 3 Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action. Mol Pharmacol. 2007 Aug;72(2):418-28.
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