Drug Details

General Information of the Drug (ID: DR2426)
Name
Mexidol
Synonyms
mexidol; 127464-43-1; 2-Ethyl-6-methylpyridin-3-ol succinate; Emoxypine succinate; UNII-2R985002CT; 2-Ethyl-3-hydroxy-6-methylpyridine Succinate; 2-Ethyl-6-methyl-3-pyridinol succinate; butanedioic acid, compd. with 2-ethyl-6-methyl-3-pyridinol (1:1); 2R985002CT; 2-Ethyl-6-methyl-3-hydroxypyridine succinate; Emicidine; Mexidole; Butanedioic acid 2-ethyl-6-methyl-3-pyridinol (1:1); ACMC-20a84f; Cambridge id 5110148; SCHEMBL1010987; DTXSID30155577; BCP13396; ANW-61453; MFCD00445612; AKOS003239209; AK-41005; DS-13730; E1069; FT-0660570; X0082; 2-Ethyl-6-methyl-3-pyridinol succinate (salt); butanedioic acid;2-ethyl-6-methylpyridin-3-ol; butanedioic acid; 2-ethyl-6-methyl-3-pyridinol; butanedioic acid; 2-ethyl-6-methyl-pyridin-3-ol; 647M960; A805706; Q-100116; Q27255507
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Molecular Type
Small molecule
Disease Ischemic stroke [ICD-11: 8B11] Phase 3 [1]
Structure
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2D MOL

3D MOL

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Formula
C12H17NO5
PubChem CID
122298
Canonical SMILES
CCC1=C(C=CC(=N1)C)O.C(CC(=O)O)C(=O)O
InChI
1S/C8H11NO.C4H6O4/c1-3-7-8(10)5-4-6(2)9-7;5-3(6)1-2-4(7)8/h4-5,10H,3H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
InChIKey
IKMNOGHPKNFPTK-UHFFFAOYSA-N
CAS Number
CAS 127464-43-1
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Citicoline      Escherichia coli     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Experimental
                    Result(s)		 In patients treated with neipilept or with the combination of citicoline with 2-ethyl-6-methyl-3-hydroxypyridine succinate, plasma phosphatidylcholine was significantly increased.
Target and Pathway
Target(s) Serotonin receptor (5HTR)  Molecule Info  [3]
References
Reference 1 ClinicalTrials.gov (NCT02793687) Study of Efficacy and Safety of MEXIDOL?
Reference 2 [The study of the membrane-protective potential of the combination of 2-ethyl-6-methyl-3-hydroxypyridine-succinate and citicoline]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(1):18-22.
Reference 3 Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba. Sci Rep. 2016 Sep 20;6:33793.
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