Drug Details

General Information of the Drug (ID: DR2507)
Name
Trolox
Synonyms
trolox; 53188-07-1; 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; TROLOX C; 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid; 6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid; 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-; MFCD00006846; 56305-04-5; CHEBI:82625; (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid; Trolox(R), 97%; 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic acid; 6-hydroxy-2,5,7,8-tetramethyl-chromane-2-carboxylic acid; EINECS 258-422-8; BRN 5052542; Trolox?; Trolox; Trolox(TM); Prestwick_855; ACMC-20apju; ACMC-1ATBW; Prestwick0_000530; Prestwick1_000530; Prestwick2_000530; Prestwick3_000530; CHEMBL153; SCHEMBL3226; 2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (+-)-; Oprea1_727377; BSPBio_000519; MLS002153860; SPBio_002440; BPBio1_000571; DTXSID60866306; HMS1569J21; HMS2096J21; HMS2230A15; HMS3369E20; HMS3713J21; HMS3885K19; BCP16474; 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid; ANW-31653; BBL103047; BDBM50359629; GEO-03688; s3665; SBB005933; STL556856; 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; AKOS015856256; CCG-207912; CS-8035; MCULE-8649288753; NCGC00179534-01; AK116067; AS-30121; SMR001233218; ST057520; DB-052268; DB-071631; HY-101445; FT-0621156; FT-0770514; Q245489; SR-01000841227; SR-01000841227-2; BRD-A17846016-001-03-0; BRD-A17846016-001-07-1; 6-hydroxy-2,5,7,8-tetramethychroman-2-carboxylic acid; 6-Hydroxy-2,5,7,8-tetramethyl-2-chromancarboxylic acid; 6-Hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid #; 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid; (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)carboxylic acid; (+/-)- 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (+/-)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, 97%; (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLICACID; 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzo-pyran-2-carboxylic Acid; 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic Acid;; 6-hydroxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
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Molecular Type
Small molecule
Disease Lung cancer [ICD-11: 2C25] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C14H18O4
PubChem CID
40634
Canonical SMILES
CC1=C(C2=C(CCC(O2)(C)C(=O)O)C(=C1O)C)C
InChI
1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChIKey
GLEVLJDDWXEYCO-UHFFFAOYSA-N
CAS Number
CAS 53188-07-1
ChEBI ID
CHEBI:82625
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Cystine      Gallus gallus     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Animal model of type 2 diabetes were used in this study.
                    Experimental
                    Result(s)		 Combination of Trolox C and cytisine are effective for the treatment of type 2 diabetes.
    β. A List of Natural Product(s) Able to Decrease the Adverse Effect of This Drug
          Arsenic trioxide      Realgar and orpiment     Click to Show/Hide the Molecular Data of This NP
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression HMOX1  Molecule Info 
Pathway MAP
Up-regulation Expression HSPA4  Molecule Info 
Pathway MAP
                    Biological
                    Regulation		 Up-regulation Cytochrome c release
                    In-vitro Model P388 CVCL_7222 Mouse lymphoma Mus musculus
                    In-vivo Model To establish xenograft model, P388 cells were injected i.p. in DBA/2 mice.
                    Experimental
                    Result(s)		 Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity.
Target and Pathway
Target(s) Bacterial DNA-3-methyladenine glycosylase 1 (Bact tag)  Molecule Info  [4]
References
Reference 1 Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells. Int J Mol Med. 2012 Feb;29(2):245-51.
Reference 2 Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes. J Transl Med. 2014 May 31;12:153.
Reference 3 Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity. Leukemia. 2007 Oct;21(10):2117-27.
Reference 4 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
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