Drug Details

General Information of the Drug (ID: DR2724)
Name
Sodium selenite
Synonyms
Disodium selenite; 10102-18-8; Natriumselenit; disodium;selenite; UNII-HIW548RQ3W; MFCD00003489; Selenious acid, sodium salt (1:2); Sodium selenite, anhydrous; HIW548RQ3W; CHEBI:48843; 10102-18-8(disodiumsalt)7782-82-3(monosodiumsalt); Natriumselenit [German]; Selenite sodium; Selenious Acid Disodium Salt; Sodium selenite, 44-46% Se, anhydrous; CCRIS 1260; HSDB 768; EINECS 233-267-9; NA2630; Sodium-selenite; H2-O3-Se.1/2Na; Aselend (TN); Selenious acid, sodium salt (2:1); Sodium Selenite,(S); Sodium selenite (JAN); Sodium selenite anhydrous; EC 233-267-9; DSSTox_CID_12077; DSSTox_RID_78904; DSSTox_GSID_32077; CHEMBL112302; DTXSID0032077; Tox21_202977; AKOS015912461; Sodium selenite [NA2630] [Poison]; NCGC00260523-01; 14013-56-0; CAS-10102-18-8; D10530; SODIUM SELENITE HIGH PURITY GRADE 100G; Q414626
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Molecular Type
Small molecule
Disease Breast cancer [ICD-11: 2C60] Phase 2 [1]
Structure
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2D MOL

3D MOL

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Formula
Na2O3Se
PubChem CID
24934
Canonical SMILES
[O-][Se](=O)[O-].[Na+].[Na+]
InChI
1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
InChIKey
BVTBRVFYZUCAKH-UHFFFAOYSA-L
CAS Number
CAS 10102-18-8
DrugBank ID
DB11127
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Ginsenoside Rh2      Panax ginseng     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model HCT 116 CVCL_0291 Colon carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Sodium selenite and G-Rh2 combination have a synergistic effect on cell growth inhibition (57%) compared with sodium selenite (25%) and G-Rh2 alone (28%) after 24 hours of treatment.
Target and Pathway
Target(s) Thioredoxin reductase 1 (TXNRD1)  Molecule Info  [3]
Thioredoxin reductase 2 (TXNRD2)  Molecule Info  [3]
Thioredoxin reductase 3 (TXNRD3)  Molecule Info  [3]
References
Reference 1 ClinicalTrials.gov (NCT00188604) The Use of Selenium to Treat Secondary Lymphedema - Breast Cancer
Reference 2 Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. Arch Iran Med. 2016 Jan;19(1):23-9.
Reference 3 An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling. J Biol Chem. 2004 Sep 10;279(37):38721-9.
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