Drug Details

General Information of the Drug (ID: DR3679)
Name
Sucralfate
Synonyms
Sucralfato; Ulcerban; Ulcogant; Ulsanic; Sucralfatum; Ulcerlmin; Ulcar; Sucralfatum [INN-Latin]; Sucralfato [INN-Spanish]; OGA-6J; UNII-XX73205DH5; HSDB 3926; XX73205DH5; EINECS 259-018-4; OS 202; DB00364; Sucralfate [USAN:USP:INN:BAN:JAN]; Aluminum, hexadeca-mu-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-)))hexadeca-; Sucrose hydrogen sulfate basic aluminium salt; Sucrose octakis(hydrogen sulfate) aluminum complex; 1,2,3,3',4,4',6,6'-Octa-O-sulfo-beta-D-fructofuranosyl-alpha-D-glucopyranosid aluminium hydroxid-hydrat-salz; alpha-D-Glucopyranoside, beta-D-fructofuranosyl-, octakis(hydrogen sulfate), aluminum complex; Hexadeca-mu-hydroxytetracosahydroxy[mu8-[1,3,4,6-tetra-O-sulfo-beta-Dfructofuranosyl-alpha-D-glucopyranoside tetrakis(hydrogen sulfato)8-)]]hexadecaaluminum; Hexadeca-U-hydroxytetracosahydroxy-(U8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl-alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-))) hexadecaaluminum
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Molecular Type
Small molecule
Disease Acne vulgaris [ICD-11: ED80] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C12H54Al9O55S8
PubChem CID
121494085
Canonical SMILES
C(C1C(C(C(C(O1)OC2(C(C(C(O2)COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Al]
InChI
1S/C12H22O35S8.9Al.20H2O/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;;;;;;;;;20*1H2/q;;8*+1;;;;;;;;;;;;;;;;;;;;/p-8/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1............................./s1
InChIKey
YZPQNHUVIVIUCT-JTJNLBSYSA-F
CAS Number
CAS 54182-58-0
TTD Drug ID
D06ULU
DrugBank ID
DB00364
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Green tea catechins      Theaceae     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Male NGS/Sea Mongolian gerbils (17 weeks old) were infected with H. pylori (ATCC43504).
                    Experimental
                    Result(s)		 The CFU of Helicobacter pylori was significantly decreased by GTC-scf.
Target and Pathway
Target(s) Fibroblast growth factor 2 (FGF2)  Molecule Info  [3]
KEGG Pathway MAPK signaling pathway Click to Show/Hide
2 Ras signaling pathway
3 Rap1 signaling pathway
4 PI3K-Akt signaling pathway
5 Signaling pathways regulating pluripotency of stem cells
6 Regulation of actin cytoskeleton
7 Pathways in cancer
8 Proteoglycans in cancer
9 Melanoma
NetPath Pathway IL1 Signaling Pathway Click to Show/Hide
Pathway Interaction Database Glypican 1 network Click to Show/Hide
2 Angiopoietin receptor Tie2-mediated signaling
3 Integrins in angiogenesis
4 Syndecan-4-mediated signaling events
5 FGF signaling pathway
Reactome PI3K Cascade Click to Show/Hide
2 PIP3 activates AKT signaling
3 FGFR4 ligand binding and activation
4 FGFR3c ligand binding and activation
5 FGFR2c ligand binding and activation
6 FGFR2b ligand binding and activation
7 FGFR3 mutant receptor activation
8 Activated point mutants of FGFR2
9 Constitutive Signaling by Aberrant PI3K in Cancer
10 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
11 Syndecan interactions
12 Non-integrin membrane-ECM interactions
13 Phospholipase C-mediated cascade: FGFR1
14 Phospholipase C-mediated cascade
15 Phospholipase C-mediated cascade
16 Phospholipase C-mediated cascade
17 SHC-mediated cascade:FGFR1
18 PI-3K cascade:FGFR1
19 FRS-mediated FGFR1 signaling
20 PI-3K cascade:FGFR2
21 SHC-mediated cascade:FGFR2
22 FRS-mediated FGFR2 signaling
23 SHC-mediated cascade:FGFR3
24 FRS-mediated FGFR3 signaling
25 PI-3K cascade:FGFR3
26 FRS-mediated FGFR4 signaling
27 SHC-mediated cascade:FGFR4
28 PI-3K cascade:FGFR4
29 Negative regulation of FGFR1 signaling
30 Negative regulation of FGFR2 signaling
31 Negative regulation of FGFR3 signaling
32 Negative regulation of FGFR4 signaling
33 RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton Click to Show/Hide
2 Endochondral Ossification
3 Differentiation Pathway
4 Cardiac Hypertrophic Response
5 Syndecan interactions
6 Extracellular matrix organization
7 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
8 PIP3 activates AKT signaling
9 Cardiac Progenitor Differentiation
10 Integrated Pancreatic Cancer Pathway
11 Neural Crest Differentiation
12 miR-targeted genes in squamous cell - TarBase
13 miR-targeted genes in muscle cell - TarBase
14 miR-targeted genes in lymphocytes - TarBase
15 Signaling by FGFR
16 MicroRNAs in cardiomyocyte hypertrophy
17 Angiogenesis
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7055).
Reference 2 Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol. 2004 Jan;39(1):61-3.
Reference 3 Assessment of sucralfate coating by sequential scintigraphic imaging in radiation-induced esophageal lesions. Gastrointest Endosc. 1995 Feb;41(2):109-14.
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