Drug Details

General Information of the Drug (ID: DR3826)
Name
Donepezil
Synonyms
donepezil; 120014-06-4; Aricept; 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; HSDB 7743; CHEMBL502; 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; (S)-E2020 (free base); C24H29NO3; CHEBI:53289; 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-; donepezilo; Donepezil [INN:BAN]; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-; 142057-80-5; NSC 737535; NSC 758882; NCGC00167537-01; donepezilum; Domepezil; Donepezil (INN); Donaz (TN); PubChem22271; Spectrum_001664; Spectrum5_001662; SCHEMBL2149; Oprea1_188452; KBioSS_002144; BDBM8960; GTPL6599; SCHEMBL8265876; DTXSID8048317; KBio2_002144; KBio2_004712; KBio2_007280; AMY8939; CHEBI:145499; BCPP000253; HMS3886M11; BCP07590; EBD50998; MFCD00912833; s5073; STK003905; AKOS000277311; AKOS016842349; AC-6969; BCP9000622; CCG-268401; DB00843; MRF-0000323; AK-72906; HY-14566; I903; SBI-0206789.P001; AB0013927; FT-0601545; D07869; S-6065; 32288-EP2269989A1; 32288-EP2269990A1; 32288-EP2275420A1; 32288-EP2278970A1; 32288-EP2280010A2; 32288-EP2281815A1; 32288-EP2283811A1; 32288-EP2289882A1; 32288-EP2289886A1; 32288-EP2295417A1; 32288-EP2298758A1; 32288-EP2298759A1; 32288-EP2298761A1; 32288-EP2298772A1; 32288-EP2298776A1; 32288-EP2301933A1; 32288-EP2305640A2; 32288-EP2305664A1; 32288-EP2305675A1; 32288-EP2308839A1; 32288-EP2311823A1; 32288-EP2311827A1; AB00640013-07; AB00640013-08; AB00640013_09; AB00640013_10; 014D064; Q415081; Q-100098; BRD-A49160188-003-04-4; Z1741977105; 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one; (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one; 2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one; 2,3-dihydro-5,6-dimethoxy-2 [[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one; 2,3-dihydro-5,6-dimethoxy-2[[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one; 5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one
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Molecular Type
Small molecule
Disease Alzheimer disease [ICD-11: 8A20] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C24H29NO3
PubChem CID
3152
Canonical SMILES
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
InChI
1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
InChIKey
ADEBPBSSDYVVLD-UHFFFAOYSA-N
CAS Number
CAS 120014-06-4
ChEBI ID
CHEBI:53289
TTD Drug ID
D0NS6H
DrugBank ID
DB00843
Target and Pathway
Target(s) Acetylcholinesterase (AChE)  Molecule Info  [2]
KEGG Pathway Glycerophospholipid metabolism Click to Show/Hide
2 Cholinergic synapse
Panther Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway Click to Show/Hide
2 Muscarinic acetylcholine receptor 2 and 4 signaling pathway
3 Nicotinic acetylcholine receptor signaling pathway
Pathwhiz Pathway Phospholipid Biosynthesis Click to Show/Hide
Pathway Interaction Database ATF-2 transcription factor network Click to Show/Hide
WikiPathways Monoamine Transport Click to Show/Hide
2 Biogenic Amine Synthesis
3 Acetylcholine Synthesis
4 Integrated Pancreatic Cancer Pathway
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6599).
Reference 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).