Drug Details

General Information of the Drug (ID: DR4025)
Name
Efonidipine
Synonyms
Efonidipine; 111011-63-3; Efonidipine [INN]; Efonidipine (INN); NCGC00182046-01; NZ-105; 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; ( inverted exclamation markA)-2-[benzyl (phenyl) amino] ethyl 1,4-dihydro-2,6- dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-pyridinecarboxylate hydrochloride ethano; C34H38N3O7P; 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; DSSTox_CID_23988; DSSTox_RID_80095; DSSTox_GSID_43988; SCHEMBL49637; CHEMBL2074922; DTXSID9043988; CHEBI:146221; HMS3886A09; ACT06293; BCP14772; EX-A3998; Tox21_113418; 3603AH; AC-389; MFCD00865899; s4977; AKOS015967143; CCG-270291; CS-3623; DB09235; 2-(N-Benzylanilino)ethyl (+-)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-5-phosphononicotinate, cyclic 2,2-dimethyltrimethylene ester; HY-12502; CAS-111011-63-3; FT-0748191; D07886; Q5347555; 2-(N-Benzylanilino)ethyl (- )-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-5-phosphononicotinate, cyclic 2,2-dimethyltrimethylene ester.; 2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2$l^{5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2; E?-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2lambda(5)-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
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Molecular Type
Small molecule
Disease Diabetes mellitus [ICD-11: 5A10] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C34H38N3O7P
PubChem CID
119171
Canonical SMILES
CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5
InChI
1S/C34H38N3O7P/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45/h5-17,20,31,35H,18-19,21-23H2,1-4H3
InChIKey
NSVFSAJIGAJDMR-UHFFFAOYSA-N
CAS Number
CAS 111011-63-3
ChEBI ID
CHEBI:146221
DrugBank ID
DB09235
Target and Pathway
Target(s) TNF-related apoptosis-inducing ligand (TRAIL)  Molecule Info  [2]
KEGG Pathway Cytokine-cytokine receptor interaction Click to Show/Hide
2 FoxO signaling pathway
3 Apoptosis
4 Natural killer cell mediated cytotoxicity
5 Measles
6 Influenza A
NetPath Pathway IL2 Signaling Pathway Click to Show/Hide
2 IL4 Signaling Pathway
3 TGF_beta_Receptor Signaling Pathway
4 TNFalpha Signaling Pathway
5 Leptin Signaling Pathway
Panther Pathway Apoptosis signaling pathway Click to Show/Hide
Pathway Interaction Database TRAIL signaling pathway Click to Show/Hide
2 Caspase Cascade in Apoptosis
Reactome Ligand-dependent caspase activation Click to Show/Hide
2 Regulation by c-FLIP
3 RIPK1-mediated regulated necrosis
4 CASP8 activity is inhibited
5 Dimerization of procaspase-8
6 TRAIL signaling
WikiPathways Apoptosis Click to Show/Hide
2 Extrinsic Pathway for Apoptosis
3 Apoptosis Modulation and Signaling
4 TP53 Network
References
Reference 1 Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-Beta/SMAD-2-Dependent Signaling Pathway in Diabetic Rats. J Mol Neurosci. 2021 May 30.
Reference 2 Effects and mechanism of arsenic trioxide in combination with rmhTRAIL in multiple myeloma. Exp Hematol. 2016 Feb;44(2):125-131.e11.