Drug Details
| General Information of the Drug (ID: DR4059) | ||||
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| Name |
Methylseleninic acid
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| Synonyms |
Methaneseleninic acid; Methylselenic acid; Methylseleninic acid; 28274-57-9; methylseleninate; UNII-9900C6V162; CHEBI:77012; 9900C6V162; Methyl seleninic acid; Methaneseleninic acid, 95%; SCHEMBL772883; CHEMBL399906; DTXSID9040550; AKOS025296197; C18902; Q6823570
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| Molecular Type |
Small molecule
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| Disease | Breast cancer [ICD-11: 2C60] | Investigative | [1] | |
| Structure |
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Click to Download Mol2D MOL |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
| Formula |
CH4O2Se
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| PubChem CID | ||||
| Canonical SMILES |
C[Se](=O)O
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| InChI |
1S/CH4O2Se/c1-4(2)3/h1H3,(H,2,3)
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| InChIKey |
UEQANLFPOFICBH-UHFFFAOYSA-N
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| CAS Number |
CAS 28274-57-9
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| ChEBI ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Palmitic acid | Myrmecophilus sp. palM | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | DDIT3 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | EIF2S1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ERN1 | Molecule Info |
Pathway MAP
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| In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
| L-02 | CVCL_6926 | Ovarian cancer | Homo sapiens | |||
| In-vivo Model | For a xenograft model, 2 * 106 HepG2 cells were mixed with 50% Matrigel and injected subcutaneously into the right flank of 6-8 week-old male BALB/c athymic nude mice. | |||||
| Experimental
Result(s) |
PA may be a promising and excellent sensitizer for improving the anticancer effect of MSeA in hepatoma chemotherapy. | |||||
| Target and Pathway | ||||
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| Target(s) | Tyrosine kinase receptor Erbb2 (HER2) | Molecule Info | [3] | |
| KEGG Pathway | ErbB signaling pathway | Click to Show/Hide | ||
| 2 | Calcium signaling pathway | |||
| 3 | HIF-1 signaling pathway | |||
| 4 | Focal adhesion | |||
| 5 | Adherens junction | |||
| 6 | Pathways in cancer | |||
| 7 | Proteoglycans in cancer | |||
| 8 | MicroRNAs in cancer | |||
| 9 | Pancreatic cancer | |||
| 10 | Endometrial cancer | |||
| 11 | Prostate cancer | |||
| 12 | Bladder cancer | |||
| 13 | Non-small cell lung cancer | |||
| 14 | Central carbon metabolism in cancer | |||
| NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
| Panther Pathway | Cadherin signaling pathway | Click to Show/Hide | ||
| 2 | EGF receptor signaling pathway | |||
| Pathwhiz Pathway | Phosphatidylinositol Phosphate Metabolism | Click to Show/Hide | ||
| Pathway Interaction Database | ErbB4 signaling events | Click to Show/Hide | ||
| 2 | ErbB2/ErbB3 signaling events | |||
| 3 | ErbB receptor signaling network | |||
| 4 | a6b1 and a6b4 Integrin signaling | |||
| 5 | Validated targets of C-MYC transcriptional repression | |||
| Reactome | SHC1 events in ERBB2 signaling | Click to Show/Hide | ||
| 2 | PLCG1 events in ERBB2 signaling | |||
| 3 | PIP3 activates AKT signaling | |||
| 4 | GRB2 events in ERBB2 signaling | |||
| 5 | PI3K events in ERBB2 signaling | |||
| 6 | Constitutive Signaling by Aberrant PI3K in Cancer | |||
| 7 | Sema4D induced cell migration and growth-cone collapse | |||
| 8 | RAF/MAP kinase cascade | |||
| WikiPathways | DNA Damage Response (only ATM dependent) | Click to Show/Hide | ||
| 2 | ErbB Signaling Pathway | |||
| 3 | EGF/EGFR Signaling Pathway | |||
| 4 | Focal Adhesion | |||
| 5 | Extracellular vesicle-mediated signaling in recipient cells | |||
| 6 | Bladder Cancer | |||
| 7 | Signaling by ERBB2 | |||
| 8 | Integrated Pancreatic Cancer Pathway | |||
| 9 | Signaling Pathways in Glioblastoma | |||
| 10 | Leptin signaling pathway | |||
| 11 | miR-targeted genes in muscle cell - TarBase | |||
| 12 | Semaphorin interactions | |||
