Drug Details

General Information of the Drug (ID: DR5175)
Name
Difluoromethylornithine
Synonyms
EFLORNITHINE; 70052-12-9; Ornidyl; 2-(Difluoromethyl)ornithine; dfmo; Difluoromethylornithine; 2,5-diamino-2-(difluoromethyl)pentanoic acid; Vaniqa; alpha-Difluoromethylornithine; alpha-(Difluoromethyl)-DL-ornithine; 67037-37-0; 2-(Difluoromethyl)-DL-ornithine; Difluromethylornithine; Eflornithine free base; RMI 71782; (RS)-eflornithine; DL-.alpha.-Difluoromethylornithine; CHEMBL830; DFMO HCl; CHEBI:41948; 70052-12-9 (free base); NSC337250; Eflornithinum; Eflornitina; Eflornithinum [Latin]; Eflornitina [Spanish]; 2,5-diamino-2-(difluoromethyl)pentanoic acid.; .alpha.-DFMO HCl; DFMO (growth regulator); Eflornithine [INN:BAN]; L-DFMO;L-RMI71782;L-alpha-difluoromethylornithine; DL-alpha-(Difluoromethyl)ornithine; DL-Ornithine, monohydrochloride; MDL 71782; Eflornithine (INN); CCRIS 3295; Ornithine, 2-(difluoromethyl)-; NSC-337250; 70050-56-5; DL-Ornithine, 2-(difluoromethyl)-; BRN 2250529; alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid; D-Ornithine, 2-(difluoromethyl)-; C6H12F2N2O2; HSDB 7923; alpha-DFMO; 66640-93-5; RFI 7178; ACMC-20m6r1; Lopac0_000429; SCHEMBL26327; GTPL5176; 2-(difluoromethyl)-L-ornithine; alpha-difluoromethyl-dl-ornithine; DTXSID3020467; H-DL-(a-Difluoromethyl)Orn-OH; BCP10516; HY-B0744; 2-(difluoromethyl)ornithine (DMFO); BDBM50028197; HSCI1_000267; KM1060; MFCD00221766; AKOS006281180; CCG-204521; DB06243; SDCCGSBI-0050414.P002; NCGC00015316-02; NCGC00015316-03; NCGC00015316-06; NCGC00015316-15; NCGC00162152-01; K100; 2-difluoromethyl-2,5-diaminopentanoic acid; DB-055371; FT-0630795; FT-0720946; FT-0775156; 2-(difluoromethyl)-2,5-diaminopentanoic acid;; C07997; D07883; 020E916; Q424751; (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid; DFMO;MDL71782;RMI71782;; A-difluoromethylornithine
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Molecular Type
Small molecule
Disease African trypanosomiasis [ICD-11: 1F51] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C6H12F2N2O2
PubChem CID
3009
Canonical SMILES
C(CC(C(F)F)(C(=O)O)N)CN
InChI
1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)
InChIKey
VLCYCQAOQCDTCN-UHFFFAOYSA-N
CAS Number
CAS 70052-12-9
ChEBI ID
CHEBI:41948
TTD Drug ID
D0X7JR
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Thymoquinone      Nigella sativa     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression DNMT1  Molecule Info 
Pathway MAP
Down-regulation Expression HDAC1  Molecule Info 
Pathway MAP
Down-regulation Expression UHRF1  Molecule Info 
Pathway MAP
                    In-vitro Model Jurkat CVCL_0065 T acute lymphoblastic leukemia Homo sapiens
                    Experimental
                    Result(s)		 Thymoquinone and difluoromethylornithine (DFMO) synergistically induce apoptosis of human acute T lymphoblastic leukemia jurkat cells through the modulation of epigenetic pathways.
Target and Pathway
Target(s) Ornithine decarboxylase (ODC1)  Molecule Info  [3]
BioCyc Putrescine biosynthesis I Click to Show/Hide
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
2 IL2 Signaling Pathway
3 TGF_beta_Receptor Signaling Pathway
Panther Pathway Ornithine degradation Click to Show/Hide
2 CCKR signaling map ST
Pathwhiz Pathway Spermidine and Spermine Biosynthesis Click to Show/Hide
Pathway Interaction Database Validated targets of C-MYC transcriptional activation Click to Show/Hide
References
Reference 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5176).
Reference 2 Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways. Technol Cancer Res Treat. Jan-Dec 2020;19:1533033820947489.
Reference 3 Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
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