Drug Details

General Information of the Drug (ID: DR5708)
Name
PNC-27
Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z] Investigative [1]
TTD Drug ID
D00GNN
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Paclitaxel      Taxus brevifolia     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression MDM2  Molecule Info 
Pathway MAP
                    In-vivo Model PNC-27 was tested in an intraperitoneal mouse model of ovarian cancer.
                    Experimental
                    Result(s)		 PNC-27 could target cells surviving paclitaxel and improve its antitumor effect.
References
Reference 1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Reference 2 Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian Cancer. Ann Clin Lab Sci. 2017 May;47(3):271-281.
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